Toxicological and Nutraceutical Screening Assays of Some Artificial Sweeteners
نویسندگان
چکیده
Artificial sweeteners are food additives worldwide used instead of fructose or glucose in many diet beverages. Furthermore, beverages intake has been increasing every year. Thus, some agencies should regulate it based on toxicological studies. Debates and controversial results demonstrated, authority can revise its decision the basis new data reporting effects since cyclamate forbidden countries. Therefore, aim this study was to report about toxicity acesulfame-k, aspartame, cyclamate, which useful for agencies, determining toxic potential nutraceutical capabilities these compounds. The toxicity, antitoxicity, genotoxicity, antigenotoxicity, life expectancy assays were carried out Drosophila as an vivo model. In addition, vitro HL-60 line cell evaluate chemopreventive activity cytotoxic effect capability producing DNA damage due internucleosomal fragmentation strand breaks. methylated status cancer cells treated with tested compounds assayed a therapy. Our demonstrated that all neither nor genotoxic, whereas resulted antigenotoxic substances, except cyclamate. Aspartame showed antitoxic Drosophila. All decreased quality organism Acesulfame-k, induced comet assay, acesulfame-k generally increased methylation status. conclusion, artificial safe at concentrations genotoxicity not significantly flies. Moreover, Cyclamate protective against genotoxin Regarding potential, aspartame could be cytotoxicity shown by According assays, necrotic way main mechanism death aspartame. Finally, Acesulfame-K hypermethylated repetitive elements, hypomethylated resulting benefit humans.
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ژورنال
عنوان ژورنال: Processes
سال: 2022
ISSN: ['2227-9717']
DOI: https://doi.org/10.3390/pr10020410